Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer

Abstract Background Tumor repopulation is a major cause of radiotherapy failure.Previous investigations highlighted that dying tumor cells played vital roles in tumor repopulation through promoting proliferation of the residual tumor repopulating cells (TRCs).However, TRCs also suffer DNA damage after radiotherapy, and might undergo mitotic catastr

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CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA.

Research has demonstrated that circular RNAs (circRNAs) exert critical functions in the occurrence and progression of numerous malignant tumors.CircPRMT5 was Masters of the Universe recently reported to be involved in the pathogenesis of cancers.However, the potential role of circPRMT5 in osteosarcoma needs further investigation.In present study, o

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MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge

Abstract Numerous vaccine candidates against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are under development.The majority of vaccine candidates to date are designed to induce immune responses against the viral spike (S) protein, although different forms of S antigen have been incorporated.To evaluate the yield and immunogenicity of

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